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Article

Ceftazidime/avibactam resistance associated with L169P mutation in the omega loop of KPC-2

10 Jan 2019

Abstract excerpt

OBJECTIVES: Ceftazidime/avibactam resistance due to mutation in the omega loop of KPC-2 has been documented in vitro and in vivo. This study evaluated the mechanism of ceftazidime/avibactam resistance in a KPC-2-expressing Klebsiella pneumoniae isolated from a patient following ceftazidime/avibactam combination therapy with gentamicin for the treatment of ventilator-associated pneumonia. METHODS:...

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Share to Antibiotic Resistance in Bacteria
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PMID: 30753572
DOI: 10.1093/jac/dkz026

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