Article

Host-Informed Engineering of Glycosylation in Komagataella phaffii for Human Biantennary N-Linked Glycans

2026-07-20

Abstract excerpt

<title>Abstract</title> <p> <italic>Komagataella phaffii</italic> is a common alternative host to mammalian cell lines for heterologous production of recombinant proteins due to its cost-effectiveness and accelerated development. Its native N-linked glycosylation, however, yields high-mannose structures that differ from those commonly found on secreted recombinant proteins used in biopharmaceuticals. The feasib...

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Literature Corpus work: 555460df-2491-53dc-8ba4-01e60534b86a
DOI: 10.21203/rs.3.rs-10329002/v1

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