Plasma proteomic associates of infection mortality in UK Biobank

Abstract excerpt

<h4>Background</h4> Infectious diseases are a major cause of mortality in spite of existing public health, anti-microbial and vaccine interventions. We aimed to define plasma proteomic associates of infection mortality and then apply Mendelian randomisation (MR) to yield biomarkers that may be causally associated. <h4>Methods</h4> We used UK Biobank plasma proteomic data to associate 2,923 plasma proteins with inf...

Topics

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• Blood Proteins
• Genetic Predisposition to Disease
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide
• Protein Interaction Maps
• Proteome
• Respiratory Tract Infections
• Risk Factors

Identifiers and source

Literature Corpus work

554da52c-1c46-52cd-9707-9a441ccb6113

DOI

10.1101/2024.01.21.24301569