Article

Dimerisation and twist reversal of the Lewy fold in α-synuclein mutants with Parkinson’s disease and dementia

2026-04-09

Abstract excerpt

Dominantly inherited missense and gene dosage mutations in SNCA , the α-synuclein gene, cause familial forms of Parkinson’s disease and dementia. Here we report the structures of α-synuclein filaments from the brains of such individuals. Pathogenic mutations A53T and G51D in SNCA give rise to singlets and doublets of the Lewy fold with a left-handed helical twist in the absence of a peptide-like density for isla...

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Literature Corpus work: 55396352-dba5-5401-ac60-5cc6a2c97bed
DOI: 10.64898/2026.04.07.716933

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