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Elevation of major constitutive heat shock proteins is heat shock factor independent and essential for establishment and growth of Lgl loss and Yorkie gain mediated tumors in <i>Drosophila</i>

2021-08-31

Abstract excerpt

Cancer cells generally overexpress heat shock proteins (Hsps), the major components of cellular stress response, to overcome and survive the diverse stresses. However, the specific roles of Hsps in initiation and establishment of cancers remain unclear. Using loss of Lgl-mediated epithelial tumorigenesis in Drosophila, we induced tumorigenic somatic clones of different genetic backgrounds to examine the temporal...

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Literature Corpus work
550621e5-31e4-536a-a316-66bb5f5fb068
DOI
10.1101/2021.08.30.458144
Open publication

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Elevation of major constitutive heat shock proteins is heat shock factor independent and essential for establishment and growth of Lgl loss and Yorkie gain mediated tumors in <i>Drosophila</i>DOI 10.1101/2021.08.30.458144
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