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Article

An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers

11 Jan 2016

Abstract excerpt

Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we analyzed gene and protein expression patterns in tumors collected from current, past, and never smokers. By this route, we elucidated a distinct pattern of molecular alterations characterized by...

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PMID: 26719530
DOI: 10.1158/0008-5472.can-14-3630

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