Article

Germline TYK2 mutation and cancer risk

2022-01-29

Abstract excerpt

Deucravacitinib, a novel, selective inhibitor of TYK2 is currently under review at the FDA and EMA for treatment of moderate-to-severe plaque psoriasis. It is unclear whether recent safety concerns (i.e. elevated rates of lung cancer and lymphoma) related to similar medications (i.e. other JAK inhibitors) are shared with this novel TYK2 inhibitor. We used a partial loss-of-function variant in TYK2 (rs34536443), pr...

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Literature Corpus work: 54897356-b32f-5e5d-bb83-362fb688ab52
DOI: 10.1101/2022.01.26.22269888

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