Back to search

Article

The effect of sedentary behaviour and physical activity on 1719 diseases: a Mendelian randomisation phenome-wide association study (MR-PheWAS)

2026-04-14

Abstract excerpt

<h4>Background</h4> Higher levels of sedentary behaviour, such as leisure screen time (LST), and lower levels of physical activity are associated with diseases across multiple body systems which contribute to a large global health burden. Whether these associations are causal is unclear. The primary aim of this study is to investigate the causal effects of higher LST (given greater power) and, secondarily, lower...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
546658c4-83ba-5e89-a692-800ab7512339
DOI
10.64898/2026.04.10.26350507
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The effect of sedentary behaviour and physical activity on 1719 diseases: a Mendelian randomisation phenome-wide association study (MR-PheWAS)DOI 10.64898/2026.04.10.26350507
Assessing the causal role of physical activity and leisure sedentary behaviours with chronic obstructive pulmonary disease: a Mendelian randomisation studySemantic proximity
Sedentary lifestyle, Physical Activity, and Gastrointestinal Diseases: Evidence from Mendelian Randomization AnalysisSemantic proximity
Sedentary Behavior, Physical Activity, and Hypertension: Genetic Liability and the Role of Metabolic Factors.Semantic proximity
Genetic liability to sedentary behavior increases the risk of cardiovascular disease incidence: Evidence from the FinnGen cohort with 293,250 individualsSemantic proximity
Accelerometer-Derived and Genetically Inferred Physical Activity and Human DiseaseSemantic proximity
Sedentary lifestyle, physical activity, and gastrointestinal diseases: evidence from mendelian randomization analysis.Semantic proximity
Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study.Semantic proximity
GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease.Semantic proximity
Potential causal association between leisure sedentary behaviors, physical activity and musculoskeletal health: A Mendelian randomization study.Semantic proximity
Association of sedentary and physical activity behaviours with body composition: a genome-wide association and Mendelian randomisation studySemantic proximity
Exploring the causal relationship between sedentary behavior and cardiovascular disease: A two-sample Mendelian randomization analysis.Semantic proximity
Genome-wide polygenic risk score for muscle strength predicts lower risk for common diseases and longer life span among the Finnish population: a prospective population based cohort study of the 342 443 FinnGen participantsSemantic proximity
Select a neighboring publication to make it the new centre.