Article

Romidepsin and Tamoxifen Cooperatively Induce Senescence of Pancreatic Cancer Cells Through Downregulation of FOXM1 Expression and Induction of ROS/Lipid Peroxidation

2021-12-08

Abstract excerpt

<title>Abstract</title> <p>Although progress has been made in chemotherapeutic strategies against pancreatic cancer, overall survival has not significantly improved over the past decade. Thus, the development of better therapeutic regimens remains a high priority. Pancreatic cancer cell lines were treated with romidepsin, an inhibitor of histone deacetylase, and tamoxifen, and their effects on cell growth, signal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 544b0e51-1d59-5179-81a8-2a9f7bca917c
DOI: 10.21203/rs.3.rs-1125720/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Romidepsin and Tamoxifen Cooperatively Induce Senescence of Pancreatic Cancer Cells Through Downregulation of FOXM1 Expression and Induction of ROS/Lipid PeroxidationDOI 10.21203/rs.3.rs-1125720/v1Read

Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cellsSemantic proximity Read

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.Semantic proximity Read

Randomized double-blinded, placebo-controlled phase II trial of simvastatin and gemcitabine in advanced pancreatic cancer patients.Semantic proximity Read

Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathwaySemantic proximity Read

CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal CancerSemantic proximity Read

Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectivesSemantic proximity Read

c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cellsSemantic proximity Read

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectivesSemantic proximity Read