Article
Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.
Oncotarget - 25 Oct 2016
Bahr Julian C, Robey Robert W, Luchenko Victoria, Basseville Agnes, Chakraborty Arup R, Kozlowski Hanna, Pauly Gary T, Patel Paresma, Schneider Joel P, Gottesman Michael M, Bates Susan E
Abstract excerpt
We previously demonstrated activation of the mitogen-activated protein kinase (MAPK) pathway in a series of romidepsin-selected T-cell lymphoma cell lines as a mechanism of resistance to the histone deacetylase inhibitor (HDI), romidepsin. As Ras mutation leads to activation of both the MAPK and the phosphoinositide 3-kinase (PI3K) pathway, we examined whether combining romidepsin with small molecule pathway...
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