Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer

1 Jan 2019

Abstract excerpt

Rationale: Colorectal cancer (CRC) is one of the most common cancers worldwide.Ciclopirox olamine (CPX) has recently been identified to be a promising anticancer candidate; however, novel activities and detailed mechanisms remain to be uncovered. Methods:The cytotoxic potential of CPX towards CRC cells was examined in vitro and in vivo.The global gene expression pattern, ROS levels, mitochondrial function,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Polyamine Metabolism and Applications
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31534504
DOI: 10.7150/thno.34663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal CancerPMID 31534504Read ↗

Reactive oxygen species and colorectal cancer.Semantic proximity Read ↗

Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagySemantic proximity Read ↗

Reactive oxygen species in colorectal cancer: The therapeutic impact and its potential roles in tumor progression via perturbation of cellular and physiological dysregulated pathwaysSemantic proximity Read ↗

A Narrative Review on Therapeutic Potential of Naringenin in Colorectal Cancer: Focusing on molecular and biochemical processesSemantic proximity Read ↗

Gingerenone A induces ferroptosis in colorectal cancer via targeting suppression of SLC7A11 signaling pathwaySemantic proximity Read ↗

A novel antitumor mechanism of triptonide in colorectal cancer: inducing ferroptosis via the SLC7A11/GPX4 axisSemantic proximity Read ↗

Vulnerability of Antioxidant Drug Therapies on Targeting Nrf2-Trp53-Jdp2 Axis in Controlling the TumorigenesisSemantic proximity Read ↗

Cincumol prevents malignant phenotype of colorectal cancer cell line HCT116 via inhibiting PI3K/AKT signaling in vitro.Semantic proximity Read ↗

Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinomaSemantic proximity Read ↗

The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)Semantic proximity Read ↗

Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine DrugsSemantic proximity Read ↗

Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.