Article

Efficacy evaluation of glasedgib Sonic Hedgehog pathway inhibition with or without inotuzumab in B-ALL cells using a new co-culturing system model and a validated chemosensitivity assay

2026-05-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Glasdegib is a Sonic Hedgehog (SHH) pathway inhibitor used for treating newly diagnosed acute myeloid leukemia in elders or patients unfit for intensive chemotherapy. This study sought to demonstrate growth inhibition and increased apoptosis of B-cell acute lymphoblastic leukemia (B-ALL) in vitro under glasdegib, alone and combined with inotuzumab, using a novel co-culture syst...

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Literature Corpus work: 5440ded7-dbd8-526a-a39b-8383fe2bf79d
DOI: 10.64898/2026.05.07.723573

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