Article

ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

2022-12-27

Abstract excerpt

<h4>Summary</h4> The mTOR inhibitor, everolimus, is an important clinical management component of metastatic ER+ breast cancer. However, most patients develop resistance and progress on therapy, highlighting the need to discover strategies that increase mTOR inhibitor effectiveness. We developed ER+ breast cancer cell lines, sensitive or resistant to everolimus, and discovered that combination treatment of ONC201...

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Identifiers and source

Literature Corpus work: 5425f751-ea14-5b58-93e3-da8dd2f89751
DOI: 10.1101/2022.12.27.522019

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