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Article

A 'hot-spot' mutation alters the mechanical properties of keratin filament networks.

Nature cell biology - 1 May 2001

Ma L, Yamada S, Wirtz D, Coulombe P A

Abstract excerpt

Keratins 5 and 14 polymerize to form the intermediate filament network in the progenitor basal cells of many stratified epithelia including epidermis, where it provides crucial mechanical support. Inherited mutations in K5 or K14 result in epidermolysis bullosa simplex (EBS), a skin-fragility disorder. The impact that such mutations exert on the intrinsic mechanical properties of K5/K14 filaments is unknown. Here...

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Identifiers

PMID: 11331879
DOI: 10.1038/35074576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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