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A genetic screen identifies O-antigen as essential for <i>Rickettsia parkeri</i> survival in macrophages by protecting from inflammasomes and interferon-stimulated genes

2026-06-13

Abstract excerpt

Lipopolysaccharide (LPS) is highly immunostimulatory, yet it is evolutionarily conserved among many obligate intracellular bacteria for unknown reasons. We report a forward genetic screen to identify factors required for survival of the tick-borne obligate cytosolic pathogen Rickettsia parkeri in primary macrophages. The most critical factors were WecA and RmlD, which synthesize O-antigen, the outermost layer of...

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Literature Corpus work
54088063-dd5f-5dee-9619-bac32c147a0f
DOI
10.64898/2026.06.12.731980
Open publication

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A genetic screen identifies O-antigen as essential for <i>Rickettsia parkeri</i> survival in macrophages by protecting from inflammasomes and interferon-stimulated genesDOI 10.64898/2026.06.12.731980
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