Article

The sustained delivery of antisense oligodeoxynucleotides using biodegradable polymer microspheres

1999-01-01

Abstract excerpt

Antisense technology is a novel drug discovery method, which provides an essential tool for directly using gene sequence information to rationally design specific inhibitions of mRNA, to treat a wide range of diseases. The efficacy of naked oligodeoxynucleotides (ODNs) is relatively short lived due to rapid degradation in vivo. The entrapment of ODNs within biodegradable sustained-release delivery systems may impr...

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Literature Corpus work: 53e478da-6ca7-5a62-a895-4962f01b6fb5
DOI: 10.48780/publications.aston.ac.uk.00010986

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