Article
Enhanced intracellular uptake and inhibition of NF-kappaB activation by decoy oligonucleotide released from PLGA microspheres.
The journal of gene medicine - 1 Jun 2005
De Rosa Giuseppe, Maiuri Maria Chiara, Ungaro Francesca, De Stefano Daniela, Quaglia Fabiana, La Rotonda Maria Immacolata, Carnuccio Rosa
Abstract excerpt
BACKGROUND: Nuclear factor-kappaB (NF-kappaB) transcription factor regulates the expression of genes involved in immune response and inflammation. NF-kappaB activity can be efficiently inhibited by double-stranded oligodeoxynucleotides (ODNs). In the present study, we investigated the potential of poly(DL-lactic-co-glycolic acid) (PLGA) microspheres as delivery system for an ODN against NF-kappaB in RAW 264.7...
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