Article

Multisite NS5A Resistance Mutations Leading to Virological Breakthrough in Hepatitis C Virus Genotype 1b: A Case Report

2026-02-22

Abstract excerpt

<title>Abstract</title> <p>Background The clinical application of direct-acting antiviral agents has substantially enhanced the sustained virological response (SVR) rates in chronic hepatitis C virus (HCV) infection. Nevertheless, treatment failure continues to occur, primarily due to resistance-associated substitutions arising from HCV's high genetic variability, while real-world data on multigenic resistance i...

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Literature Corpus work: 53db205d-acdf-52c9-b5f3-6dc9e813c40e
DOI: 10.21203/rs.3.rs-8680395/v1

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