Article

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates lung injury during mechanical ventilation

2019-10-11

Abstract excerpt

<h4>ABSTRACT</h4> During mechanical ventilation, injurious biophysical forces exacerbate lung injury. These forces disrupt alveolar capillary barrier integrity, trigger proinflammatory mediator release, and differentially regulate genes and non-coding oligonucleotides such as microRNAs. In this study, we identify miR-146a as a mechanosensitive microRNA in alveolar macrophages that has therapeutic potential to mit...

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Literature Corpus work: 53cae912-5970-590b-9681-fff10614ea9c
DOI: 10.1101/796557

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