Article

Effect of Endothelium on the Anticoagulant Activity of a Covalent Antithrombin-Heparin Complex

2023-12-04

Abstract excerpt

<title>Abstract</title> <p>We have developed a covalent antithrombin-heparin complex (ATH) with superior anticoagulant properties compared to non-covalent antithrombin (AT) + unfractionated heparin (H). Previous <italic>in vitro</italic> investigations of ATH activity were done in the absence of endothelium. Since the endothelial surface can modulate hemostasis, we investigated the impact of endothelium on the an...

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Literature Corpus work: 53c35781-6f78-5ae6-82ec-56e6db6726fa
DOI: 10.21203/rs.3.rs-3679253/v1

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