Article

Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design

2010-01-01

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays crucial roles in cell growth, proliferation and survival. Genomic aberrations in the PI3K pathway, such as mutational activation of PI3Kα or loss of function of tumor suppressor PTEN, have been closely linked to the development and progression of a wide range of cancers. Hence, inhibition of the key targets in the pathway, e.g. PI3K, AKT, mTOR, offer...

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Literature Corpus work: 62c1b558-3fd6-5b60-b492-e9cc1026b8fb
DOI: 10.1039/c0md00072h

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