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Virtual Screening and Molecular Docking: Discovering Novel c-KIT Inhibitors.

Current medicinal chemistry - 1 Jan 2022

Tavares Fernanda Mello, Gomes Angela Cristina, Assunção Edson Mareco, de Medeiros João Luiz Sobral, Scotti Marcus T, Scotti Luciana, Ishiki Hamilton Mitsugu

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are unusual cancers, which are developed in specialized cells in the gastrointestinal tract wall. Various strategies involving single-agents, combinations, and rapid complementary inhibitor cycling are now being used to control such tumors. Based on promising early clinical trial experience, certain novel KIT and PDGFRA tyrosine kinase inhibitors have shown advanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34525909
DOI: 10.2174/0929867328666210915102920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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