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Article

BRG1 targeting overcomes ABCC-based multidrug resistance induced by paclitaxel

2025-05-07

Abstract excerpt

Multidrug resistance of cancer cells is attributed to drug-induced alteration of numerous intracellular processes. Using clinically relevant models of triple-negative breast and non-small lung cancer cells we previously showed that these cells respond to repeated paclitaxel exposure by inter alia lysosome enrichment in ABCC3, ABCC5 and ABCC10, which contribute to drug sequestration in these organelles and reduced...

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Literature Corpus work
539a0a2c-d4e6-5907-b453-1daae736384d
DOI
10.1101/2025.05.01.651609
Open publication

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BRG1 targeting overcomes ABCC-based multidrug resistance induced by paclitaxelDOI 10.1101/2025.05.01.651609
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