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Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm

30 Apr 2024

Abstract excerpt

BACKGROUND: Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of the mechanisms underlying AAA development and progression. ATF3 (activating transcription factor 3) has been increasingly recognized as a key regulator of cardiovascular diseases. However, the role of ATF3 in AAA development and progression remains elusive. METHODS:...

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PMID: 38686580
DOI: 10.1161/circresaha.124.324323

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