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Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitors

1 Jan 2017

Abstract excerpt

/M phase in the human lung cancer cell line (A549), inhibiting tubulin polymerization leading to apoptosis. Further, Hoechst staining, decrease in mitochondrial membrane potential and Annexin V-FITC assay suggested that the cell death was due to apoptosis induction. Overall, the present investigation demonstrated that the synthesized imidazopyridine-propenone conjugates are promising tubulin inhibitors and...

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PMID: 30108815
DOI: 10.1039/c7md00043j

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