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TFE3 and HIF1a regulates the expression of SHMT2 isoforms via alternative promoter utilization in ovarian cancer cells

2024-10-18

Abstract excerpt

<title>Abstract</title> <p>Ovarian cancer ranks first lethally among gynecological malignancies. Platinum-based chemotherapy constitutes the first-line therapeutic regime. However, primary or acquired resistance seriously affects the survival rate of patients with ovarian cancer. Serine hydroxy methyltransferase (SHMT) catalyzes conversion of serine to glycine and is responsible for production of S-adenosylmethio...

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Literature Corpus work
52d6ad46-0751-5cef-b160-e9396764752f
DOI
10.21203/rs.3.rs-4981006/v1
Open publication

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