Article

Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

2020-02-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>PURPOSE</h4> Estrogen receptor (ER) positive breast cancer is frequently sensitive to endocrine therapy. Multiple mechanisms of endocrine therapy resistance have been identified, including cancer stem-like cell (CSC) activity. Sulforaphane (SFN) has previously been shown to target CSCs but its mechanism of action is unclear. Here we investigate SFX-01, a stabilised formulation of SFN, for i...

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Literature Corpus work: 52b16fcc-07d9-533b-a2ce-87f103136a18
DOI: 10.1101/2020.02.03.932194

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