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Article

Resistance to PARP Inhibitors: Lessons from Preclinical Models of BRCA-Associated Cancer

2018-11-28

Abstract excerpt

Inhibitors of poly(ADP-ribose) polymerase (PARP) have recently entered the clinic for the treatment of homologous recombination–deficient cancers. Despite the success of this approach, resistance to PARP inhibitors (PARPis) is a clinical hurdle, and it is poorly understood how cancer cells escape the deadly effects of PARPis without restoring BRCA1/2 function. By synergizing the advantages of next-generation seque...

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Literature Corpus work
52a9823e-7849-54fc-a898-cdd2731529f0
DOI
10.1146/annurev-cancerbio-030617-050232
Open publication

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Resistance to PARP Inhibitors: Lessons from Preclinical Models of BRCA-Associated CancerDOI 10.1146/annurev-cancerbio-030617-050232
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