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PARP Inhibitors in Breast and Ovarian Cancer

18 Apr 2023

Abstract excerpt

Poly (ADP-ribose) polymerase (PARP) inhibitors are one of the most successful examples of clinical translation of targeted therapies in medical oncology, and this has been demonstrated by their effective management of BRCA1/BRCA2 mutant cancers, most notably in breast and ovarian cancers. PARP inhibitors target DNA repair pathways that BRCA1/2-mutant tumours are dependent upon. Inhibition of the key components of...

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PMID: 37190285
DOI: 10.3390/cancers15082357

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