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Article

PARP inhibitor resistance: the underlying mechanisms and clinical implications

20 Jun 2020

Abstract excerpt

Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) polymerase (PARP) have been approved for ovarian cancer and breast cancer indications. However, PARPi resistance is ubiquitous in clinic. More than 40% BRCA1/2-deficient patients fail to respond to PARPi. In...

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PMID: 32563252
DOI: 10.1186/s12943-020-01227-0

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