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Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid

1 Aug 2022

Abstract excerpt

Advances in adeno-associated virus (AAV) engineering have provided exciting new tools for research and potential solutions for gene therapy. However, the lung has not received the same tailored engineering as other major targets of debilitating genetic disorders. To address this, here we engineered the surface-exposed residues AA452-458 of AAV9 capsid proteins at the three-fold axis of symmetry and employed a...

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PMID: 35990749
DOI: 10.1016/j.omtm.2022.07.010

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