Article

The tail domain of neurofilament light chain accumulates in neuronal nuclei during oxidative injury

2022-03-04

Abstract excerpt

Neurofilament light chain (NFL), one of the major subunits of neuron-specific intermediate filaments, is an important component of the neuronal cytoskeleton. Mutations in the NEFL gene and disturbances of NFL turnover or transport are associated with the pathophysiology of various diseases of the nervous system. Also, NFL is released from neurons as a result of neuroaxonal damage and NFL levels in cerebrospinal f...

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Literature Corpus work: 5269845c-56d7-5c1d-b8ba-780a23d66ef1
DOI: 10.1101/2022.03.03.481279

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