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Article

Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs

20 Jul 2018

Abstract excerpt

Neurofilaments (NFs) are the most abundant cytoskeletal component of vertebrate myelinated axons. NFs function by determining axonal caliber, promoting axonal growth and forming a 3-dimensional lattice that supports the organization of cytoplasmic organelles. The stoichiometry of NF protein subunits (NFL, NFM and NFH) has to be tightly controlled to avoid the formation of NF neuronal cytoplasmic inclusions...

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PMID: 30029677
DOI: 10.1186/s13041-018-0386-3

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