Article

Desialylated platelets promote hepatocyte proliferation via the ERK1/2 signaling pathway

2026-07-27

Abstract excerpt

Platelets are increasingly recognized as active regulators of tissue repair and liver regeneration beyond their classical roles in hemostasis and thrombosis. Loss of terminal sialic acid from platelet surface glycoproteins, a process known as desialylation, occurs during platelet aging or activation and has been linked to platelet clearance via the asialoglycoprotein receptor (ASGPR) on hepatocytes. However, the m...

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Literature Corpus work: 523329ca-7d07-5450-925f-40ededfdcddd
DOI: 10.64898/2026.07.26.740293

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