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Ex-vivo Expansion of Bone Marrow-derived Mesenchymal Stromal Cells for Clinical Use: the Starting Platelet Concentration of Human Platelet Lysate Affects Cell Proliferation, Senescence and Phenotype

2023-05-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: In the last decades the replacement of fetal bovine serum (FBS) with human Platelet Lysate (hPL) for ATMPs expansion has been for a long time investigated to overcome FBS-related issues. Despite several studies confirming hPL safety and efficacy in Mesenchymal Stromal Cell (MSC) expansion, there are still gaps in the knowledge of hPL as a supplement, like the co...

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Literature Corpus work
e41654d3-1e69-5cdf-b7a9-11004f933c99
DOI
10.21203/rs.3.rs-2760525/v1
Open publication

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Ex-vivo Expansion of Bone Marrow-derived Mesenchymal Stromal Cells for Clinical Use: the Starting Platelet Concentration of Human Platelet Lysate Affects Cell Proliferation, Senescence and PhenotypeDOI 10.21203/rs.3.rs-2760525/v1
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