CD117/c-kit in Cancer Stem Cell-Mediated Progression and Therapeutic Resistance

Abstract excerpt

<h4>ABSTRACT</h4> Metastasis is the primary cause of cancer patient morbidity and mortality but due to persisting gaps in our knowledge, it remains untreatable. Metastases often occur as patients' tumors progress or recur after initial therapy. Tumor recurrence at the primary site may be driven by a cancer stem-like cell or tumor progenitor cell, while recurrence at a secondary site is driven by metastatic cancer...

Topics

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• Cell Proliferation
• Models, Biological
• Molecular Targeted Therapy
• Mutation
• Neoplasms
• Protein Kinase Inhibitors
• Proto-Oncogene Proteins c-kit
• Signal Transduction

Identifiers and source

Literature Corpus work

51fcdd87-df4f-537d-94da-57dec553c963

DOI

10.1101/256099