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Multi-Omics Integrative Analysis of the Aspirin-Gut-Brain-Glioma Axis: Transcriptomic, Proteomic, Epigenetic, Mendelian Randomization, and Single-Cell Transcriptomic Evidence Converges on NEO1/Hepcidin Iron Reprogramming and Ferroptosis Vulnerability

2026-06-02

Abstract excerpt

<h4>Background</h4> Despite epidemiological interest in aspirin’s chemopreventive potential against glioma, the underlying multi-layered molecular mechanisms — spanning gut microbial ecology, COX-2/PGE2 signaling, inter-organ iron homeostasis via the NEO1/hepcidin regulatory axis, epigenetic reprogramming, and ferroptosis — have not been systematically characterized at the multi-omics level. <h4>Methods</h4> We...

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Literature Corpus work
51cd001b-0acf-5b67-9050-ae763d066be2
DOI
10.64898/2026.06.01.26354602
Open publication

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Multi-Omics Integrative Analysis of the Aspirin-Gut-Brain-Glioma Axis: Transcriptomic, Proteomic, Epigenetic, Mendelian Randomization, and Single-Cell Transcriptomic Evidence Converges on NEO1/Hepcidin Iron Reprogramming and Ferroptosis VulnerabilityDOI 10.64898/2026.06.01.26354602
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