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Article

Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006

Rosas Lucia E, Snider Heidi M, Barbi Joseph, Satoskar Anjali A, Lugo-Villarino Geanncarlo, Keiser Tracy, Papenfuss Tracy, Durbin Joan E, Radzioch Danuta, Glimcher Laurie H, Satoskar Abhay R

Abstract excerpt

T-bet and STAT1 regulate IFN-gamma gene transcription in CD4+ T cells, which mediate protection against Leishmania. Here we show that T-bet and STAT1 are required for the induction of an efficient Th1 response during Leishmania donovani infection, but they play distinct roles in determining disea...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16785492
DOI: 10.4049/jimmunol.177.1.22

Genes

STAT1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16785492-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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