Article

Conformationally restricted JHA enables picomolar mosquito control through affinity–efficacy decoupling

2026-08-19

Abstract excerpt

<title>Abstract</title> <p> Conventional ligand optimization has traditionally focused on increasing binding affinity, but these gains seldom translate into proportional improvements in functional efficacy. This creates a bottleneck for developing next-generation biorational pesticides. Juvenile hormone analogs (JHAs), such as S-methoprene, are safe, target-specific insect growth regulators, yet their practical...

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Identifiers and source

Literature Corpus work: 51131aef-0c36-57eb-ba93-78fbcd4a653f
DOI: 10.21203/rs.3.rs-10065095/v1

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