Article

Increased Mitochondrial Mass Related To Heightened Pyroptosis of CD4+T Cells In HIV-1 Infection

2021-04-28

Abstract excerpt

<h4>Background: </h4> In HIV-1 infection, over 90% CD4 + T cells die of caspase-1 mediated pyroptosis. What governs the increased susceptibility of CD4 + T cells to pyroptosis is poorly understood. <h4>Method: </h4> Blood samples were obtained from 31 ART-naive HIV-infected patients, 29 ART-exposed HIV-infected patients, and 21 healthy control donors. Plasma levels of IL-18 and IL-1β, activated caspase-1, mitochon...

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Literature Corpus work: 50d61b7c-0a2e-5ba9-b906-016a545a1526
DOI: 10.21203/rs.3.rs-445797/v1

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