Article

Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammation

2025-01-08

Abstract excerpt

Loss-of-function mutations in the human OTULIN gene, encoding a deubiquitinase with exclusive specificity for linear ubiquitin chains, cause a severe multi-organ autoinflammatory condition involving the skin 1,2 . Mice lacking OTULIN selectively in keratinocytes develop inflamed skin lesions that progress into squamous tumours, a phenotype driven by excessive TNF-induced cell death 3,4 . Previous studies sugges...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0bae7b5b-1445-5cf7-a707-a8e7574376c2
DOI: 10.1101/2025.01.08.631848

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammationDOI 10.1101/2025.01.08.631848Read

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and AutoimmunitySemantic proximity Read

A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome.Semantic proximity Read

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosisSemantic proximity Read

Dominant negative OTULIN Related Autoinflammatory SyndromeSemantic proximity Read

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked PolyubiquitinSemantic proximity Read

The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathologySemantic proximity Read

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.Semantic proximity Read

OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.Semantic proximity Read

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.Semantic proximity Read

Pyoderma gangrenosum caused by the molecular uncoupling of OTULIN catalytic activity and LUBAC binding.Semantic proximity Read

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastomaSemantic proximity Read

OTULIN in NF-κB signaling, cell death, and diseaseSemantic proximity Read