Article

Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary cilia

2025-02-25

Abstract excerpt

<h4>Aims</h4> Bicuspid aortic valve (BAV), where two valve leaflets are found instead of the usual three, affects 1-2% of the general population and is associated with significant morbidity and mortality. Despite its frequency, the majority of cases remain unexplained. This is, at least in part, because there are two types of valve leaflet primordia: endocardial cushions and intercalated valve swellings (ICVS). M...

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Literature Corpus work: 509f8699-4dce-56f4-b5f5-0ca480a87ca9
DOI: 10.1101/2025.02.25.636485

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