Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve caused by loss of primary cilia.

Cardiovascular research - 29 Sept 2025

Alqahtani Ahlam, Eley Lorraine, Newton Jake, McDonald Kimberley, Connolly Chloe, Rodrigues-Cleto Cindy, Neffeova Kristyna, Lopez Leonor, Arias Javier, Derrick Christopher J, Alaradi Mashael, Kolesova Hana, Chaudhry Bill, Henderson Deborah J

Abstract excerpt

AIMS: Bicuspid aortic valve (BAV), where two valve leaflets are found instead of the usual three, affects 1-2% of the general population and is associated with significant morbidity and mortality. Despite its frequency, the majority of cases remain unexplained. This is, at least in part, because there are two types of valve leaflet primordia: endocardial cushions and intercalated valve swellings (ICVS). Moreover,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Valve
Share to Bicuspid Aortic Valve Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Valve Diseases

Share to Neural Crest

Share to Receptors, Notch

Share to Tumor Suppressor Proteins

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 40498626
DOI: 10.1093/cvr/cvaf108
PMCID: PMC12477680

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve caused by loss of primary cilia.PMID 40498626Read ↗

Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary ciliaSemantic proximity Read ↗

A role for primary cilia in aortic valve development and diseaseSemantic proximity Read ↗

Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic StenosisSemantic proximity Read ↗

Ciliopathies in Complex Congenital Heart Disease: Molecular Genetics, Embryologic Mechanisms and Clinical Implications.Semantic proximity Read ↗

New Concepts in the Development and Malformation of the Arterial ValvesSemantic proximity Read ↗

Functions of cilia in cardiac development and diseaseSemantic proximity Read ↗

Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitorsSemantic proximity Read ↗

Congenital heart defects caused by FOXJ1Semantic proximity Read ↗

Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitors.Semantic proximity Read ↗

A change of heart: new roles for cilia in cardiac development and diseaseSemantic proximity Read ↗

Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart fieldSemantic proximity Read ↗

Outflow Tract Formation—Embryonic Origins of Conotruncal Congenital Heart DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.