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Article

Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field

20 Sept 2018

Abstract excerpt

ABSTRACT The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impact cardiovascular outflow tract development. Detailed 3D reconstructions, immunohistochemistry and...

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Share to Aortic Disease and Treatment Approaches
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PMID: 30242109
DOI: 10.1242/dmm.034637

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