Article

CD18-mediated adhesion is required for lung inflammation induced by mononuclear cell-derived extracellular vesicles

2017-06-30

Abstract excerpt

Extracellular vesicles are submicron vesicles that upregulate the synthesis of proinflammatory mediators by lung epithelial cells. We investigated whether these structures adhere to lung epithelial cells, and whether adhesion is a prerequisite for their proinflammatory activity. Extracellular vesicles were generated by stimulation of normal human mononuclear cells with the calcium ionophore A23187, and labelled wi...

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Literature Corpus work: 505ee718-5493-55eb-8efc-74a207dd719b
DOI: 10.1101/158121

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