Article

Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection

2020-03-22

Abstract excerpt

COVID-19 has become a global pandemic caused by a novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis and for drug discovery and vaccine development. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike gene and in other genes among bat, pangolin and human coronaviruses, indicating similar strong evolutionary...

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Literature Corpus work: 503f6764-d6fc-5cd8-8e65-c6cab3c5ceea
DOI: 10.1101/2020.03.20.000885

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