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Synonymous mutations and the molecular evolution of SARS-CoV-2 origins

5 Dec 2020

Abstract excerpt

Abstract Human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is most closely related, by average genetic distance, to two coronaviruses isolated from bats, RaTG13 and RmYN02. However, there is a segment of high amino acid similarity between human SARS-CoV-2 and a pangolin-isolated strain, GD410721, in the receptor-binding domain (RBD) of the spike protein, a pattern that can be caused by either...

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PMID: 33500788
DOI: 10.1093/ve/veaa098

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