Article

Synergistic Stimulation of Osteoblast Differentiation of Rat Mesenchymal Stem Cells by Leptin and 25(OH)D3 is Mediated by Inhibition of Chaperone-Mediated Autophagy

2021-05-24

Abstract excerpt

<h4>Background: </h4> 25(OH)D 3 is important for the osteoblast differentiation of bone marrow mesenchymual stem cells (BMMSCs), BMMSCs can directly hydroxylate 25(OH)D 3 to 1α,25(OH) 2 D 3 to induce osteoblast differentiation. Our previous research with human BMMSCs showed that the cell membrane receptor megalin is required for the 25(OH)D 3 -DBP complex to enter cells and thereby to stimulate osteoblast differen...

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Literature Corpus work: 50280ca8-38f3-54a9-b10e-3317b5d8ad0a
DOI: 10.21203/rs.3.rs-547605/v1

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