Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic High Dose Alcohol Induces Osteopenia via Activation of mTOR Signaling in Bone Marrow Mesenchymal Stem Cells.

Stem cells (Dayton, Ohio) - 1 Aug 2016

Liu Yao, Kou Xiaoxing, Chen Chider, Yu Wenjing, Su Yingying, Kim Yong, Shi Songtao, Liu Yi

Abstract excerpt

Chronic consumption of excessive alcohol results in reduced bone mass, impaired bone structure, and increased risk of bone fracture. However, the mechanisms underlying alcohol-induced osteoporosis are not fully understood. Here, we show that high dose chronic alcohol consumption reduces osteogenic differentiation and enhances adipogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs), leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipogenesis
Share to Bone Diseases, Metabolic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone Marrow Cells

Share to Ethanol

Share to Mesenchymal Stem Cells

Share to Mice, Nude

Share to Sirolimus

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 27145264
DOI: 10.1002/stem.2392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic High Dose Alcohol Induces Osteopenia via Activation of mTOR Signaling in Bone Marrow Mesenchymal Stem Cells.PMID 27145264Read ↗

Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic DifferentiationSemantic proximity Read ↗

Targeting the mTOR-Autophagy Axis: Unveiling Therapeutic Potentials in OsteoporosisSemantic proximity Read ↗

mTORC1 Signaling Promotes Osteoblast Differentiation from PreosteoblastsSemantic proximity Read ↗

PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasisSemantic proximity Read ↗

Huc-MSC-derived exosomes alleviates alcohol-induced osteonecrosis of the femoral head through targeting the miR-25-3p/GREM1 axisSemantic proximity Read ↗

The Impact of Obesity on Autophagy in Human Adipose-Derived Mesenchymal Stromal CellsSemantic proximity Read ↗

HIF1A overexpression promotes osteoblast differentiation through activation of autophagy to alleviate osteoporosisSemantic proximity Read ↗

Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem CellsSemantic proximity Read ↗

Loss-of-Function of HtrA1 Abrogates All-Trans Retinoic Acid-Induced Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Through Deficiencies in p70S6K Activation.Semantic proximity Read ↗

A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on BoneSemantic proximity Read ↗

Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.Semantic proximity Read ↗

Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.