Article

Stable iPSC-derived NKX2-1 <sup>+</sup> Lung Bud Tip Progenitor Organoids Give Rise to Airway and Alveolar Cell Types

2022-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Bud tip progenitors (BTPs) in the developing lung give rise to all epithelial cell types found in the airways and alveoli. The current work aimed to develop an iPSC organoid model enriched with stable NKX2-1 + BTP-like cells. Building on prior work, we optimized a directed differentiation paradigm to generate spheroids with robust NKX2-1 expression. Spheroids were expanded into organoids that p...

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Literature Corpus work: 4fe7c910-22fd-54ce-92bd-e817482b053d
DOI: 10.1101/2022.02.25.481981

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